Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 7/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569345 | 0.82 | CASR (0.45) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL8565689 | 0.82 | CASR (0.45) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL8565687 | 0.82 | CASR (0.45) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL4824743 | 0.77 | HPGD (0.51) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL1545033 | 0.77 | CA2 (0.56) | CA2LMNA | |
| SCHEMBL23856953 | 0.76 | LMNA (0.42) | HPGDPKMLMNA | |
| SCHEMBL7476692 | 0.74 | CASR (0.45) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL21490280 | 0.74 | HPGD (0.45) | CASRHPGDHTR1ANISCHCA2 | |
| SCHEMBL17150937 | 0.74 | CASR (0.50) | CASRHPGDHTR1ANISCHBRD4 | |
| SCHEMBL30112409 | 0.74 | CASR (0.50) | CASRHPGDHTR1ANISCHBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348426-B1 | Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents | DR. REDDY'S LABORATIES LIMITED (IN) | 2008-03-25 | — | — | US | disclosed |
| CN-1353699-A | Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents | REDDY RESEARCH FOUNDATION (IN) | 2002-06-12 | — | — | CN | disclosed |