Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | ELOC | Q15369 | 1/20 | 0.40 |
| ▸ | ELOB | Q15370 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | PPOX | P50336 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8474486 | 0.77 | METAP1 (0.44) | METAP1SRD5A1HPGDHTR2AHTR2C | |
| SCHEMBL5113686 | 0.77 | SRD5A1 (0.38) | SRD5A1HPGDHTTPARP1PARP10 | |
| SCHEMBL2818053 | 0.77 | TDP2 (0.43) | CES1MAOAMAOBPRKCI | |
| SCHEMBL8169678 | 0.77 | METAP1 (0.44) | METAP1S100A4SRD5A1SRD5A2L3MBTL1 | |
| SCHEMBL15186910 | 0.74 | HTR2A (0.45) | METAP1AHRHTR2AHTR2CHTR2B | |
| SCHEMBL31029247 | 0.74 | CASP1 (0.59) | METAP1S100A4VHLELOCELOB | |
| SCHEMBL28603 | 0.74 | CASP1 (0.59) | METAP1S100A4VHLELOCELOB | |
| SCHEMBL2819249 | 0.73 | HTR2A (0.42) | HTR2AHTR2CHTR2BMAOAMAOB | |
| SCHEMBL8162469 | 0.73 | TDP2 (0.49) | SRD5A1HPGDL3MBTL1HTTMAPT | |
| SCHEMBL972858 | 0.73 | METAP1 (0.50) | METAP1HPGDHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384960-B2 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-06-10 | — | — | US | disclosed |
| US-20050192332-A1 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2005-09-01 | — | — | US | disclosed |
| US-6906080-B1 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2005-06-14 | — | — | US | disclosed |
| EP-1230244-B1 | PYRAZOLECARBOXYLIC ACID TRICYCLIC DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-01-19 | — | — | EP | disclosed |
| EP-1230244-A2 | PYRAZOLECARBOXYLIC ACID TRICYCLIC DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032663-A2 | PYRAZOLECARBOXYLIC ACID TRICYCLIC DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2001-05-10 | — | — | WO | disclosed |
| US-5886016-A | ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5670532-A | Pyrazolyl derivatives for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5565482-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5547975-A | ANTIARTHRIC AGENTS, ANALGESICS AND ANTIPYRETICS; INHIBITORS OF CYCLOOXYGENASE II; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 1996-08-20 | — | — | US | disclosed |
| WO-1996009304-A1 | BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192332-A1 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | CNR1, CNR2, CBR3 | METAP1 4707/4885S100A4 1776/4885VHL 4507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.