Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.94 |
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenoprofen SCHEMBL435081 | 1.00 | PTGS1 (0.94) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL6269014 | 1.00 | PTGS1 (0.94) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL8706502 | 0.98 | PTGS1 (0.97) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL4081 | 0.98 | PTGS1 (0.97) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL3797 | 0.97 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL8754928 | 0.97 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL11336376 | 0.97 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| (S)-Fenoprofen SCHEMBL4492279 | 0.97 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| R-Fenoprofen SCHEMBL4082 | 0.97 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| R-Fenoprofen SCHEMBL30910976 | 0.97 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1587798-A4 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | MERCK & CO INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060063937-A1 | Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents | MERCK SHARP & DOHME CORP. | 2006-03-23 | — | — | US | disclosed |
| EP-1587798-A2 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | Merck & Co., Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004064771-A2 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | MERCK & CO., INC. (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063937-A1 | Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents | APP, PSEN1, CA1 | PTGS1 20/4885PTGS2 59/4885MEN1 1296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.