Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | GOT1 | P17174 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123581 | 0.91 | GAA (0.46) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5119242 | 0.87 | GAA (0.43) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5123484 | 0.86 | GAA (0.45) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5125861 | 0.85 | DRD2 (0.44) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5124846 | 0.81 | GAA (0.48) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5117828 | 0.80 | DRD2 (0.46) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5114444 | 0.79 | DRD2 (0.47) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5112763 | 0.78 | MEN1 (0.48) | GAADRD3DRD2DRD4MEN1 | |
| SCHEMBL5113484 | 0.77 | GAA (0.54) | GAADRD3DRD2DRD4MAPT | |
| SCHEMBL5117069 | 0.77 | DRD2 (0.47) | GAADRD3DRD2DRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342015-B2 | Indole derivatives | H. LUNDBECK A/S (DK) | 2008-03-11 | — | — | US | claimed |
| US-20060258678-A1 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 2006-11-16 | — | — | US | claimed |
| EP-1399434-B1 | NOVEL INDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2005-09-07 | — | — | EP | claimed |
| EP-1399434-A1 | NOVEL INDOLE DERIVATIVES | H. Lundbeck A/S (DK) | 2004-03-24 | — | — | EP | claimed |
| WO-2003002552-A1 | NOVEL INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2003-01-09 | — | — | WO | claimed |
| US-7342015-B2 | Indole derivatives | H. LUNDBECK A/S (DK) | 2008-03-11 | — | — | US | disclosed |
| US-20060258678-A1 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 2006-11-16 | — | — | US | disclosed |
| EP-1399434-B1 | NOVEL INDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2005-09-07 | — | — | EP | disclosed |
| EP-1399434-A1 | NOVEL INDOLE DERIVATIVES | H. Lundbeck A/S (DK) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002552-A1 | NOVEL INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258678-A1 | Novel indole derivatives | IDO1, TPH1, HTR5A | GAA 2020/4885DRD3 25/4885DRD2 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.