Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533550 | 0.82 | HCRTR1 (0.47) | MEN1KMT2AMAPTTSHRTP53 | |
| SCHEMBL532980 | 0.81 | JAK2 (0.48) | GFERMEN1KMT2ASLC40A1MAPT | |
| SCHEMBL532939 | 0.78 | EDNRA (0.43) | GFERMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL532038 | 0.78 | ALDH1A1 (0.54) | GFERKMT2ASLC40A1MAPTTSHR | |
| SCHEMBL534052 | 0.78 | MEN1 (0.47) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL533512 | 0.77 | SLC22A12 (0.44) | MEN1KMT2ASLC40A1MAPTTSHR | |
| SCHEMBL533083 | 0.76 | EDNRA (0.46) | MAPTALDH1A1 | |
| SCHEMBL6363732 | 0.75 | GFER (0.98) | GFERMEN1KMT2AMAPTTSHR | |
| SCHEMBL532999 | 0.75 | TP53 (0.48) | MEN1KMT2ATP53ALDH1A1CYP3A4 | |
| SCHEMBL532998 | 0.75 | JAK2 (0.37) | GFERMEN1KMT2AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |