Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14078195 | 0.95 | TRPM8 (0.56) | TRPM8LPAR1LPAR5KMT2AHTT | |
| Trifluoroacetic Acid SCHEMBL5106762 | 0.91 | TRPM8 (0.62) | TRPM8KMT2ARAB9ARAF1MAP2K1 | |
| Trifluoroacetic Acid SCHEMBL5114908 | 0.91 | TRPM8 (0.59) | TRPM8LPAR1FFAR4LPAR5KMT2A | |
| SCHEMBL14078270 | 0.89 | TRPM8 (0.51) | TRPM8LPAR1LPAR5KMT2AHTT | |
| Trifluoroacetic Acid SCHEMBL5320030 | 0.88 | TRPM8 (0.56) | TRPM8FFAR4KMT2AHTTRAB9A | |
| SCHEMBL14078273 | 0.87 | TRPM8 (0.54) | TRPM8LPAR1LPAR5KMT2ATSHR | |
| SCHEMBL5187485 | 0.85 | LPAR1 (0.48) | TRPM8LPAR1LPAR5KMT2AHTT | |
| SCHEMBL5107779 | 0.85 | TRPM8 (0.62) | TRPM8LPAR1LPAR5KMT2AHTT | |
| Trifluoroacetic Acid SCHEMBL5111898 | 0.85 | TRPM8 (0.54) | TRPM8LPAR1LPAR5KMT2ARAF1 | |
| SCHEMBL14078347 | 0.84 | TRPM8 (0.69) | TRPM8KMT2ARAB9ARAF1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214654-A1 | Substituted Benzyloxy-Phenylmethylamide Derivatives | BAYER HEALTHCARE AG (DE) | 2008-09-04 | — | — | US | disclosed |
| EP-1802600-A1 | SUBSTITUTED 4-BENZYLOXY-PHENYLMETHYLAMIDE DERIVATIVES AS COLD MENTHOL RECEPTOR-1 (CMR-1) ANTAGONITS FOR THE TREATMENT OF UROLOGICAL DISORDERS | Bayer HealthCare AG (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040136-A1 | SUBSTITUTED 4-BENZYLOXY-PHENYLMETHYLAMIDE DERIVATIVES AS COLD MENTHOL RECEPTOR-1 (CMR-1) ANTAGONISTS FOR THE TREATMENT OF UROLOGICAL DISORDER | BAYER HEALTHCARE AG (DE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214654-A1 | Substituted Benzyloxy-Phenylmethylamide Derivatives | OPRL1, ADRA1A, CNR1 | TRPM8 124/4885LPAR1 210/4885FFAR4 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.