Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | PDE4A | P27815 | 2/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31619806 | 1.00 | TSHR (0.66) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL11967263 | 1.00 | TSHR (0.66) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL5113232 | 1.00 | TSHR (0.66) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL31620968 | 0.94 | TSHR (0.59) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL31632614 | 0.94 | TSHR (0.59) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL21621325 | 0.93 | TSHR (0.59) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL31620983 | 0.93 | TSHR (0.57) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL31620981 | 0.92 | TSHR (0.56) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL25773363 | 0.92 | TSHR (0.56) | TSHRMAPK1MAPTCYP3A4TDP1 | |
| SCHEMBL25773255 | 0.90 | TSHR (0.54) | TSHRMAPK1MAPTCYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10710998-B2 | Compound and process | VERONA PHARMA PLC (GB) | 2020-07-14 | — | — | US | disclosed |
| US-20190330206-A1 | NEW COMPOUND AND PROCESS | VERONA PHARMA LIMITED (GB) | 2019-10-31 | — | — | US | disclosed |
| EP-3490988-B1 | NEW COMPOUND AND PROCESS | VERONA PHARMA PLC (GB) | 2019-08-28 | — | — | EP | disclosed |
| US-20120302533-A1 | DERIVATIVES OF PYRIMIDO [6,1-A] ISOQUINOLIN-4-ONE | VERONA PHARMA PLC (GB) | 2012-11-29 | — | — | US | disclosed |
| US-8242127-B2 | INHIBITORS OF PHOSPHODIESTERASE (PDE) ISOENZYMES; USEFUL FOR TREATMENT OF RESPIRATORY DISORDERS SUCH AS ASTHMA; chronic obstructive pulmonary disease (COPD); 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2012-08-14 | — | — | US | disclosed |
| US-20080206163-A1 | Derivatives of pyrimido[6, 1-A]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2008-08-28 | — | — | US | disclosed |
| US-7378424-B2 | Derivatives of pyrimido[6, 1-A]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2008-05-27 | — | — | US | disclosed |
| US-7105663-B2 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | RHINOPHARMA LIMITED (CA) | 2006-09-12 | — | — | US | disclosed |
| US-6794391-B2 | INHIBITORS OF PHOSPHODIESTERASE (PDE) ISOENZYMES; USEFUL FOR TREATMENT OF RESPIRATORY DISORDERS SUCH AS ASTHMA. | VERNALIS LIMITED (GB) | 2004-09-21 | — | — | US | disclosed |
| US-20040176353-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED | 2004-09-09 | — | — | US | disclosed |
| US-20040171828-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED | 2004-09-02 | — | — | US | disclosed |
| EP-1165558-B1 | DERIVATIVES OF PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE | VERNALIS LTD (GB) | 2003-09-24 | — | — | EP | disclosed |
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED (GB) | 2003-06-26 | — | — | US | disclosed |
| US-20030036542-A1 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2003-02-20 | — | — | US | disclosed |
| EP-1165558-A1 | DERIVATIVES OF PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE | Vernalis Limited (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058308-A1 | DERIVATIVES OF PYRIMIDO[6,1-a]ISOQUINOLIN-4-ONE | VERNALIS LIMITED (GB) | 2000-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302533-A1 | DERIVATIVES OF PYRIMIDO [6,1-A] ISOQUINOLIN-4-ONE | PDE4A, PDE2A, PDE12 | TSHR 4570/4885MAPK1 2113/4885MAPT 4655/4885 |
| US-20030036542-A1 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one | CXCR6, HRH1, HRH2 | TSHR 483/4885MAPK1 2115/4885MAPT 4791/4885 |
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | CCR6, CXCR6, HRH1 | TSHR 1084/4885MAPK1 2175/4885MAPT 4711/4885 |
| US-20190330206-A1 | NEW COMPOUND AND PROCESS | RPL4, EIF5B, RPLP2 | TSHR 4279/4885MAPK1 2255/4885MAPT 3273/4885 |
| US-20040176353-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | TAS1R2, TAS2R1, TAS2R7 | TSHR 665/4885MAPK1 1118/4885MAPT 4517/4885 |
| US-10710998-B2 | Compound and process | RPL4, EIF5B, RPLP1 | TSHR 4409/4885MAPK1 2487/4885MAPT 3018/4885 |
| US-20040171828-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | TAS2R1, TAS2R7, TAS2R50 | TSHR 700/4885MAPK1 1333/4885MAPT 4637/4885 |
| US-20080206163-A1 | Derivatives of pyrimido[6, 1-A]isoquinolin-4-one | HRH2, HRH4, TAS2R3 | TSHR 368/4885MAPK1 1893/4885MAPT 4699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.