TAS1R2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL700816	0.73	16/20
SCHEMBL700604	1.00	15/20
SCHEMBL700763	1.00	15/20
SCHEMBL700898	1.00	15/20
SCHEMBL701856	1.00	15/20
SCHEMBL701881	0.74	15/20
SCHEMBL701253	1.00	14/20
SCHEMBL701799	1.00	14/20
SCHEMBL701895	1.00	14/20
SCHEMBL517318	0.72	14/20
SCHEMBL700840	1.00	13/20
SCHEMBL700841	1.00	13/20
SCHEMBL701854	1.00	13/20
SCHEMBL701855	1.00	13/20
SCHEMBL701892	1.00	13/20
SCHEMBL701897	1.00	13/20
SCHEMBL701828	0.74	13/20
SCHEMBL701795	1.00	12/20
SCHEMBL517994	0.72	12/20
SCHEMBL517895	0.67	12/20

Clinical trials — most relevant to TAS1R2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN
Study of Taste Deficits	nan	COMPLETED
Genetic Variability in Taste Perception	nan	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
Sensitive Periods in Early Flavor Learning	nan	COMPLETED
Astringency and Oral Health	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents	nan	NOT_YET_RECRUITING
Taste Perception and Chronic Disease Risk	nan	COMPLETED
The Obese Taste Bud Study	nan	UNKNOWN
Impacts of Sugar-Sweetened Beverage on Body Weight	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TAS1R2 binder may also engage these)

Protein	Name	Similarity
A3QNZ8	—	1.000	A3QNZ8 →
A3QNZ9	—	1.000	A3QNZ9 →
A3QP00	—	1.000	A3QP00 →
A3QP07	—	1.000	A3QP07 →
A3QP01	—	1.000	A3QP01 →
Q49HI0	—	1.000	Q49HI0 →
Q925I4	—	1.000	Q925I4 →
A3QP09	—	1.000	A3QP09 →
A3QP08	—	1.000	A3QP08 →
Q9Z0R7	—	1.000	Q9Z0R7 →
Q6TAC4	—	0.997	Q6TAC4 →
Q9PW88	—	0.993	Q9PW88 →
O70410	—	0.993	O70410 →
Q9Z0R8	—	0.992	Q9Z0R8 →
Q923K1	—	0.992	Q923K1 →
CASR	Extracellular calcium-sensing receptor	0.991	landscape →
Q99PG6	—	0.990	Q99PG6 →
P48442	—	0.989	P48442 →
Q5U9X3	—	0.988	Q5U9X3 →
Q9QY96	—	0.988	Q9QY96 →
O62714	—	0.987	O62714 →
TAS1R1	Taste receptor type 1 member 1 (G protein-cou	0.987	landscape →
Q925D8	—	0.987	Q925D8 →
E1BPQ3	—	0.987	E1BPQ3 →
Q70VB1	—	0.986	Q70VB1 →
Q8K4Z6	—	0.985	Q8K4Z6 →
Q5T6X5	—	0.984	Q5T6X5 →
Q8R420	—	0.983	Q8R420 →
P35384	—	0.983	P35384 →
E9Q6I0	—	0.983	E9Q6I0 →