Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14098165 | 0.91 | TDP2 (0.41) | TDP2ERN1PARP1PARP2ALDH1A1 | |
| SCHEMBL14098170 | 0.82 | ESR1 (0.43) | TDP2ALDH1A1LMNAMCL1BCL2 | |
| SCHEMBL14098169 | 0.79 | ALDH1A1 (0.39) | TDP2PARP1PARP2ALDH1A1LMNA | |
| SCHEMBL14098177 | 0.78 | ALOX5 (0.40) | TDP2ALDH1A1LMNAPGRESR1 | |
| SCHEMBL14098162 | 0.78 | ERN1 (0.40) | ERN1PARP1PARP2ALDH1A1LMNA | |
| SCHEMBL14098147 | 0.78 | TDP2 (0.42) | TDP2ERN1PARP1PARP2ALDH1A1 | |
| SCHEMBL5113427 | 0.78 | ERN1 (0.39) | TDP2ERN1PARP1PARP2ALDH1A1 | |
| SCHEMBL14098171 | 0.77 | ALDH1A1 (0.41) | ALDH1A1LMNAMCL1BCL2ESR1 | |
| SCHEMBL14138951 | 0.76 | ALDH1A1 (0.33) | ALDH1A1LMNA | |
| SCHEMBL7109725 | 0.76 | ALDH1A1 (0.58) | ALDH1A1LMNAMCL1BCL2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| EP-1182200-B1 | TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | NIPPON SUISAN KAISHA LTD (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-20040127713-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SUISAN KAISHA, LTD. | 2004-07-01 | — | — | US | disclosed |
| US-6700013-B2 | O-BROMOPHENYLACETIC ACID DERIVATIVE CHEMICAL INTERMEDIATE; SMOOTH MUSCLE RELAXANTS, ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | NIPPON SUISAN KAISHA, LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| US-20030220360-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SUISAN KAISHA, LTD., A JAPAN CORPORATION | 2003-11-27 | — | — | US | disclosed |
| US-6602898-B1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SUISAN KAISHA, LTD. (JP) | 2003-08-05 | — | — | US | disclosed |
| EP-1182200-A9 | TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Nippon Suisan Kaisha, Ltd. (JP) | 2002-05-22 | — | — | EP | disclosed |
| EP-1182200-A1 | TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Nippon Suisan Kaisha, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220360-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | HRH2, HRH1, HRH4 | TDP2 3386/4885ERN1 2144/4885PARP1 1098/4885 |
| US-20040127713-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | HRH2, HRH1, HRH4 | TDP2 3386/4885ERN1 2144/4885PARP1 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.