Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.68 |
| ▸ | CLCN2 | P51788 | 2/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457079 | 0.85 | GABRA1 (0.69) | GABRA1GABRB2CLCN2HMGB1MRGPRX4 | |
| SCHEMBL10363062 | 0.83 | GABRA1 (0.62) | GABRA1GABRB2MRGPRX4TSHRALDH1A1 | |
| SCHEMBL1457739 | 0.82 | GABRA1 (1.00) | GABRA1GABRB2TSHRALDH1A1TDP1 | |
| SCHEMBL3771988 | 0.79 | KDM4E (0.52) | GABRA1GABRB2HMGB1TSHRALDH1A1 | |
| SCHEMBL10594316 | 0.77 | CYP3A4 (0.47) | GABRA1GABRB2HMGB1TSHRALDH1A1 | |
| SCHEMBL4037990 | 0.75 | CYP3A4 (0.46) | GABRA1GABRB2CLCN2MRGPRX4TSHR | |
| SCHEMBL1022432 | 0.75 | GABRA1 (0.78) | GABRA1GABRB2ALDH1A1HSD17B10 | |
| SCHEMBL109349 | 0.75 | GABRA1 (0.78) | GABRA1GABRB2TSHRALDH1A1HPGD | |
| SCHEMBL31152354 | 0.75 | GABRA1 (0.78) | GABRA1GABRB2ALDH1A1HSD17B10 | |
| SCHEMBL10615737 | 0.75 | GABRA1 (0.78) | GABRA1GABRB2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2623087-B1 | Dental composite materials containing tricyclic plasticisers | VOCO GMBH (DE) | 2019-07-17 | — | — | EP | disclosed |
| EP-2623086-B1 | Curable mixture comprising plasticisers with a polyalicyclic structure element for use in the production of dental materials. | VOCO GMBH (DE) | 2019-07-10 | — | — | EP | disclosed |
| EP-2623087-A2 | Dental composite materials containing tricyclic plasticisers | VOCO GmbH (DE) | 2013-08-07 | — | — | EP | disclosed |
| EP-2623086-A2 | Curable mixture comprising plasticisers with a polyalicyclic structure element for use in the production of dental materials. | VOCO GmbH (DE) | 2013-08-07 | — | — | EP | disclosed |
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
| US-20050042674-A9 | Common ligand mimics: thiazolidinediones and rhodanines | TRIAD THERAPEUTICS, INC. | 2005-02-24 | — | — | US | disclosed |
| US-20050019825-A9 | Common ligand mimics: pseudothiohydantoins | TRIAD THERAPEUTICS, INC. | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050019825-A9 | Common ligand mimics: pseudothiohydantoins | FGFR3, BID, FLT3 | GABRA1 361/4885GABRB2 567/4885CLCN2 2833/4885 |
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | REN, PKD1, NR3C2 | GABRA1 2625/4885GABRB2 3479/4885CLCN2 2549/4885 |
| US-20050042674-A9 | Common ligand mimics: thiazolidinediones and rhodanines | GPR65, NR2E3, FGFR3 | GABRA1 484/4885GABRB2 615/4885CLCN2 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.