Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | FAP | Q12884 | 4/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12413549 | 0.84 | EPHX1 (0.42) | EPHX1CXCR4FAPPREPALDH1A1 | |
| SCHEMBL9892338 | 0.79 | EPHX1 (0.58) | EPHX1FAPPREPSIGMAR1HPGD | |
| SCHEMBL22173356 | 0.79 | CXCR4 (0.47) | EPHX1CXCR4FAPALDH1A1KDM4E | |
| SCHEMBL3531779 | 0.79 | CXCR4 (0.47) | EPHX1CXCR4FAPALDH1A1KDM4E | |
| SCHEMBL22170013 | 0.79 | CXCR4 (0.47) | EPHX1CXCR4FAPALDH1A1KDM4E | |
| SCHEMBL22174969 | 0.79 | CXCR4 (0.47) | EPHX1CXCR4FAPALDH1A1KDM4E | |
| SCHEMBL5113769 | 0.78 | EPHX1 (0.73) | EPHX1CXCR4ALDH1A1KDM4EEPHX2 | |
| SCHEMBL22317357 | 0.77 | PREP (0.37) | FAPPREPALDH1A1 | |
| SCHEMBL5416045 | 0.76 | EPHX1 (0.70) | EPHX1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16316312 | 0.76 | POLB (0.50) | EPHX1ALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414067-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1610776-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060069256-A1 | Ophthalmic compositions for treating ocular hypertension | EVOTEC OAI (GB) | 2006-03-30 | — | — | US | disclosed |
| EP-1610776-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co. Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087051-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069256-A1 | Ophthalmic compositions for treating ocular hypertension | KCNN1, KCNN3, KCNN2 | EPHX1 1491/4885CXCR4 4468/4885FAP 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.