Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5113679 | 0.84 | EPHX1 (0.45) | EPHX1PDK1PDK2PDK3PDK4 | |
| SCHEMBL16330211 | 0.79 | EPHX1 (0.43) | EPHX1EPHX2KDM4EALDH1A1KMT2A | |
| SCHEMBL19652077 | 0.75 | EPHX1 (0.57) | EPHX1EPHX2KMT2APREPFAP | |
| SCHEMBL1709299 | 0.75 | EPHX1 (0.57) | EPHX1EPHX2KMT2APREPFAP | |
| SCHEMBL23481547 | 0.74 | PDK1 (0.63) | EPHX1PDK1PDK2PDK3PDK4 | |
| SCHEMBL9611268 | 0.74 | PDK1 (0.63) | EPHX1PDK1PDK2PDK3PDK4 | |
| SCHEMBL9892338 | 0.73 | EPHX1 (0.58) | EPHX1HPGDSMN1; SMN2HSD17B10PREP | |
| SCHEMBL18624748 | 0.72 | EPHX1 (0.53) | EPHX1EPHX2KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL15131910 | 0.72 | POLB (0.41) | KDM4EALDH1A1SMN1; SMN2PREPFAP | |
| SCHEMBL9611267 | 0.71 | ALDH1A1 (0.61) | EPHX1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | EPHX1 1666/4885PDK1 2928/4885PDK2 3868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.