Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120048 | 0.74 | SRD5A1 (0.55) | SRD5A2SRD5A1HSP90AA1CA1CA2 | |
| SCHEMBL11658676 | 0.65 | SRD5A2 (0.55) | SRD5A2SRD5A1KDM4EKMT2AGAA | |
| SCHEMBL7918742 | 0.62 | ALDH1A1 (0.54) | SRD5A2CA1CA2KDM4ETP53 | |
| SCHEMBL11566981 | 0.62 | AKR1B1 (0.44) | SRD5A2SRD5A1CA1CA2KDM4E | |
| Acetic Acid SCHEMBL28167102 | 0.62 | HSP90AA1 (0.57) | SRD5A2SRD5A1HSP90AA1CA1CA2 | |
| SCHEMBL1697496 | 0.61 | TSHR (0.69) | SRD5A2KDM4EKMT2ATP53SMN1; SMN2 | |
| SCHEMBL5106774 | 0.60 | METAP1 (0.44) | SRD5A2SRD5A1HTTMETAP1MAPT | |
| SCHEMBL13864431 | 0.60 | MAPT (0.50) | KDM4EHSD17B3KMT2AGAATP53 | |
| SCHEMBL10905860 | 0.60 | — | — | |
| SCHEMBL4025662 | 0.59 | SRD5A1 (0.61) | SRD5A2SRD5A1HSP90AA1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384960-B2 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-06-10 | — | — | US | disclosed |
| US-20050192332-A1 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2005-09-01 | — | — | US | disclosed |
| US-6906080-B1 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2005-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192332-A1 | Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same | CNR1, CNR2, CBR3 | SRD5A2 724/4885SRD5A1 562/4885HSP90AA1 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.