Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067241 | 0.80 | ALDH1A1 (0.42) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22157991 | 0.80 | NPC1 (0.49) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9489536 | 0.78 | NPC1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5120680 | 0.77 | ALDH1A1 (0.39) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL12263425 | 0.77 | ALDH1A1 (0.39) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5127248 | 0.77 | ALDH1A1 (0.44) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5116843 | 0.71 | MAPT (0.52) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Ethylamine SCHEMBL6158093 | 0.70 | NPC1 (0.58) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22299325 | 0.70 | CYP2A6 (0.42) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL16996824 | 0.69 | GRM6 (0.52) | MAPTNPC1RAB9AHPGDLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | PTPA, PTPRJ, PTPRR | MAPT 3063/4885NPC1 3349/4885RAB9A 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.