Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067241 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TDO2MAPTRAB9ACYP3A4 | |
| SCHEMBL27900520 | 0.77 | ALDH1A1 (0.43) | ALDH1A1TDO2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5114023 | 0.77 | MAPT (0.47) | ALDH1A1TDO2MAPTRAB9ACYP3A4 | |
| SCHEMBL12263425 | 0.75 | ALDH1A1 (0.39) | ALDH1A1TDO2MAPTRAB9ACYP3A4 | |
| SCHEMBL5127248 | 0.75 | ALDH1A1 (0.44) | ALDH1A1TDO2MAPTRAB9ACYP3A4 | |
| SCHEMBL22299324 | 0.70 | ALDH1A1 (0.39) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9489536 | 0.68 | NPC1 (0.47) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10567172 | 0.67 | ALDH1A1 (0.46) | ALDH1A1TDO2MAPTCYP3A4CYP1A2 | |
| SCHEMBL544880 | 0.67 | TDO2 (0.42) | ALDH1A1TDO2MAPTRAB9ACYP3A4 | |
| SCHEMBL1983048 | 0.66 | BRD4 (0.33) | ALDH1A1MAPTRAB9ACYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | PTPA, PTPRJ, PTPRR | ALDH1A1 1266/4885TDO2 2021/4885MAPT 3063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.