SCHEMBL51142

SCHEMBL51142

C/C(O)=C(\C#N)C(=O)Nc1cc(Br)ccc1Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 1.00
ALDH1A1 P00352 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
GAA P10253 1/20 1.00
CYP2C9 P11712 1/20 1.00
PKM P14618 1/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
LMNA P02545 1/20 1.00
THRB P10828 1/20 1.00
BLM P54132 1/20 1.00
BTK Q06187 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
PLK3 Q9H4B4 1/20 1.00
DHODH Q02127 18/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL51144 1.00 MEN1 (1.00) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL29394998 1.00 MEN1 (1.00) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL51143 1.00 MEN1 (1.00) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL5914885 0.89 ALDH1A1 (0.80) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL5914888 0.89 ALDH1A1 (0.80) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL28057335 0.84 MEN1 (0.70) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL5914906 0.82 MEN1 (0.70) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL5914905 0.82 MEN1 (0.70) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL5914890 0.79 DHODH (0.70) MEN1ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL5914891 0.79 DHODH (0.70) MEN1ALDH1A1KMT2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4531856-B1 BRUTON'S KINASE INHIBITORS FOR THE TREATMENT OF A SUDDEN ALLERGIC REACTION ALK ABELLO AS (DK) 2026-04-22 EP claimed
US-20260102468-A1 COMPOSITIONS AND METHODS FOR MARCO INHIBITION AND IMPROVED DRUG DELIVERY UNIV TEXAS (US) 2026-04-16 US claimed
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC (US) 2026-04-09 US claimed
US-20260028675-A1 PRECISION MEDICINE FOR PAIN: DIAGNOSTIC BIOMARKERS, PHARMACOGENOMICS, AND REPURPOSED DRUGS UNIV INDIANA RES & TECH CORP (US) 2026-01-29 US claimed
US-20260014140-A1 DOSAGES OF IMMUNOCONJUGATES OF ANTIBODIES AND SN-38 FOR IMPROVED EFFICACY AND DECREASED TOXICITY IMMUNOMEDICS INC (US) 2026-01-15 US claimed
US-20250361307-A1 COMBINATION THERAPIES FOR TREATING HYPERPROLIFERATIVE DISORDERS X4 PHARMACEUTICALS INC (US) 2025-11-27 US claimed
EP-4629993-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS Kartos Therapeutics (US) 2025-10-15 EP claimed
US-20250295655-A1 BRUTON'S KINASE INHIBITORS FOR THE TREATMENT OF A SUDDEN ALLERGIC REACTION Alk-Abelló A/S (DK) 2025-09-25 US claimed
EP-4531856-A1 BRUTON'S KINASE INHIBITORS FOR THE TREATMENT OF A SUDDEN ALLERGIC REACTION ALK-Abelló A/S (DK) 2025-04-09 EP claimed
US-12268681-B2 Methods of treating myeloproliferative neoplasms KARTOS THERAPEUTICS, INC. (US) 2025-04-08 US claimed
US-20220054648-A1 ANTIBODY-DRUG CONJUGATES AND USES THEREOF IMMUNOMEDICS, INC. 2022-02-24 US claimed
US-11253606-B2 Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer IMMUNOMEDICS, INC. (US) 2022-02-22 US claimed
EP-3954373-A1 NEOADJUVANT USE OF ANTIBODY-DRUG CONJUGATES Immunomedics, Inc. (US) 2022-02-16 EP claimed
US-9976172-B2 Method and apparatus for measuring protein post-translational modification ICAGEN, INC. (US) 2018-05-22 US claimed
US-9820987-B2 Modulator compounds of drug resistance in epithelial tumor cells BIONSIL S.R.L. IN LIQUIDAZIONE (IT) 2017-11-21 US claimed
WO-2017042706-A1 PHARMACEUTICAL KIT AND USE OF ERYTHROPOIETIN AND BRUTON'S KINASE INHIBITOR UNIWERSYTET MEDYCZNY W BIAŁYMSTOKU (PL) 2017-03-16 WO claimed
US-20160201111-A1 Method and Apparatus for Measuring Protein Post-Translational Modification UNITED STATES GOVERNMENT 2016-07-14 US claimed
US-20150111953-A1 Modulator Compounds of Drug Resistance in Epithelial Tumor Cells BIONSIL S.R.L. IN LIQUIDAZIONE (IT) 2015-04-23 US claimed
US-8129356-B2 Bmx mediated signal transduction in irradiated vascular endothelium VANDERBILT UNIVERSITY (US) 2012-03-06 US claimed
US-20090136487-A1 BMX MEDIATED SIGNAL TRANSDUCTION IN IRRADIATED VASCULAR ENDOTHELIUM VANDERBILT UNIVERSITY 2009-05-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028675-A1 PRECISION MEDICINE FOR PAIN: DIAGNOSTIC BIOMARKERS, PHARMACOGENOMICS, AND REPURPOSED DRUGS MYLK3, MYL12A, MYLK2 MEN1 4427/4885ALDH1A1 4727/4885KMT2A 3198/4885
US-12268681-B2 Methods of treating myeloproliferative neoplasms JAK2, JAK1, PDPK1 MEN1 1475/4885ALDH1A1 586/4885KMT2A 445/4885
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms JAK2, TP53, CDKN1A MEN1 1822/4885ALDH1A1 1814/4885KMT2A 1324/4885
US-20260014140-A1 DOSAGES OF IMMUNOCONJUGATES OF ANTIBODIES AND SN-38 FOR IMPROVED EFFICACY AND DECREASED TOXICITY CD74, CD2, CD274 MEN1 1668/4885ALDH1A1 1361/4885KMT2A 4014/4885
US-20150111953-A1 Modulator Compounds of Drug Resistance in Epithelial Tumor Cells BTK, PRKDC, PCLAF MEN1 3314/4885ALDH1A1 4313/4885KMT2A 1708/4885
US-20250295655-A1 BRUTON'S KINASE INHIBITORS FOR THE TREATMENT OF A SUDDEN ALLERGIC REACTION BTK, SYK, ABL1 MEN1 3540/4885ALDH1A1 4690/4885KMT2A 1325/4885
US-20260102468-A1 COMPOSITIONS AND METHODS FOR MARCO INHIBITION AND IMPROVED DRUG DELIVERY MSR1, TNFRSF9, TNFSF10 MEN1 1176/4885ALDH1A1 4392/4885KMT2A 3061/4885
US-20250361307-A1 COMBINATION THERAPIES FOR TREATING HYPERPROLIFERATIVE DISORDERS CXCR6, BCL6, CXCR4 MEN1 1767/4885ALDH1A1 2271/4885KMT2A 1586/4885
US-11253606-B2 Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer PARP2, DOCK2, DYNLL2 MEN1 4148/4885ALDH1A1 3269/4885KMT2A 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.