Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586842 | 0.76 | KLK7 (0.46) | ALDH1A1HPGDTDP1LMNAHSD17B10 | |
| SCHEMBL24470352 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDLMNAKDM4EHSD17B10 | |
| SCHEMBL399205 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDTDP1LMNAKDM4E | |
| SCHEMBL3540163 | 0.74 | TDP1 (0.48) | ALDH1A1HPGDTDP1KDM4EHSD17B10 | |
| SCHEMBL4587988 | 0.69 | LMNA (0.49) | ALDH1A1HPGDTDP1LMNAKDM4E | |
| SCHEMBL3508193 | 0.69 | NQO2 (0.47) | ALDH1A1HPGDTDP1LMNAKDM4E | |
| SCHEMBL394063 | 0.67 | NQO2 (0.46) | ALDH1A1HPGDTDP1LMNAKDM4E | |
| SCHEMBL7320772 | 0.67 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNAKDM4EHSD17B10 | |
| SCHEMBL3504817 | 0.66 | NQO2 (0.49) | ALDH1A1HPGDTDP1LMNAKDM4E | |
| SCHEMBL2112079 | 0.65 | ALDH1A1 (0.69) | ALDH1A1HPGDTDP1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080103170-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2008-05-01 | — | — | US | disclosed |
| CN-101119994-A | Nicotinic acetycholine receptor ligands | ASTRAZENECA AB (SE) | 2008-02-06 | — | — | CN | disclosed |
| EP-1831212-A1 | NICOTINIC ACETYCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065217-A1 | NICOTINIC ACETYCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103170-A1 | Nicotinic Acetylcholine Receptor Ligands | CHRNG, CHRNE, CHRNA1 | ALDH1A1 1028/4885HPGD 669/4885TDP1 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.