Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.59 |
| ▸ | ITGAV | P06756 | 2/20 | 0.53 |
| ▸ | CFD | P00746 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114489 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL6599162 | 0.82 | KDM4E (0.77) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7094858 | 0.81 | DRD2 (0.60) | KDM4EALDH1A1HSD17B10HDAC1HDAC2 | |
| SCHEMBL7739589 | 0.80 | HDAC1 (0.77) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL13133298 | 0.80 | KDM4E (0.81) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL630515 | 0.79 | SRD5A2 (1.00) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7139266 | 0.79 | SRD5A2 (0.65) | SRD5A2HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL18900668 | 0.79 | KDM4E (0.75) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL31159466 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7740477 | 0.78 | HDAC1 (0.93) | KDM4EALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |