Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.52 |
| ▸ | GRK2 | P25098 | 10/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | PRKCB | P05771 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789558 | 0.81 | CYP3A4 (0.62) | ROCK2GRK2ROCK1CYP3A4CIT | |
| SCHEMBL5109024 | 0.80 | ROCK2 (0.67) | ROCK2GRK2PRKCAGRK3GRK5 | |
| SCHEMBL5122984 | 0.78 | CAMKK2 (0.51) | ROCK2GRK2ROCK1JAK2RPS6KA5 | |
| SCHEMBL5122742 | 0.78 | ROCK2 (0.45) | ROCK2GRK2CDK2GSK3BDYRK1A | |
| SCHEMBL13887911 | 0.76 | CYP3A4 (0.61) | ROCK2ROCK1CYP3A4CITMAP3K7 | |
| SCHEMBL14289640 | 0.76 | ADORA2A (0.44) | ROCK2GRK2ROCK1 | |
| SCHEMBL5117005 | 0.75 | TSHR (0.45) | ROCK2GRK2ROCK1GSK3BCDK5 | |
| SCHEMBL14289641 | 0.74 | JAK3 (0.47) | ROCK2ROCK1JAK2RPS6KA5PRKCG | |
| SCHEMBL298441 | 0.73 | NEK2 (0.60) | ROCK1CYP3A4CITMAP3K7JAK2 | |
| SCHEMBL13887909 | 0.73 | CYP3A4 (0.69) | ROCK2ROCK1CYP3A4CITMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | ROCK2 2/4885GRK2 254/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.