Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | LATS1 | O95835 | 1/20 | 0.44 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789988 | 0.84 | PDPK1 (0.49) | JAK3GPR84DYRK1ACDC7LATS1 | |
| SCHEMBL5122984 | 0.83 | CAMKK2 (0.51) | JAK3DYRK1ACDC7CDK2CDK9 | |
| SCHEMBL5122742 | 0.77 | ROCK2 (0.45) | DYRK1ACDC7PDPK1CDK2RET | |
| SCHEMBL5117005 | 0.76 | TSHR (0.45) | DYRK1APDPK1CDK9CDK5CAMKK2 | |
| SCHEMBL14311088 | 0.76 | CDC7 (0.48) | JAK3DYRK1ACDC7CDK2CDK9 | |
| SCHEMBL14289640 | 0.75 | ADORA2A (0.44) | CDC7PDPK1CAMKK2ROCK2ROCK1 | |
| SCHEMBL5115939 | 0.74 | CAMKK2 (0.46) | JAK3DYRK1ACDC7CDK2CDK9 | |
| SCHEMBL1050911 | 0.74 | TGFBR1 (0.60) | GPR84DYRK1ACDC7PDPK1TGFBR1 | |
| SCHEMBL5114855 | 0.74 | ROCK2 (0.52) | JAK3DYRK1ACDK2CDK5CCNA2 | |
| SCHEMBL30689228 | 0.72 | SMN1; SMN2 (0.58) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | JAK3 1534/4885GPR84 3129/4885DYRK1A 1338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.