Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSPA5 | P11021 | 4/20 | 0.50 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.50 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12376694 | 0.81 | RAB9A (0.66) | KMT2AMEN1RAB9AHDAC1HPGD | |
| Hydrochloric Acid SCHEMBL27550180 | 0.79 | RAB9A (0.56) | KMT2AMEN1RAB9AHDAC1HPGD | |
| Hydrochloric Acid SCHEMBL27550181 | 0.79 | RAB9A (0.56) | KMT2AMEN1RAB9AHDAC1HPGD | |
| SCHEMBL19976901 | 0.79 | GAA (0.59) | KMT2AMEN1RAB9AHPGDHSPA5 | |
| SCHEMBL355263 | 0.79 | — | — | |
| SCHEMBL13753488 | 0.78 | RAB9A (0.62) | KMT2AMEN1RAB9AHDAC1HPGD | |
| SCHEMBL23804606 | 0.78 | HSPA5 (0.78) | KMT2AMEN1HSPA5HSPA2HSPA9 | |
| SCHEMBL4755708 | 0.77 | RAB9A (0.57) | KMT2AMEN1RAB9AHDAC1HPGD | |
| SCHEMBL13222414 | 0.76 | RAB9A (0.60) | RAB9AHDAC1HPGDHSPA5HSPA2 | |
| SCHEMBL3038390 | 0.76 | RAB9A (0.60) | KMT2AMEN1RAB9AHDAC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | KMT2A 3700/4885MEN1 2513/4885RAB9A 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.