Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115659 | 0.94 | PKM (0.58) | PKMCHRM2LMNAALDH1A1MEN1 | |
| SCHEMBL5125577 | 0.89 | PKM (0.47) | PKMLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5125308 | 0.88 | PKM (0.56) | PKMCHRM2LMNAMEN1MAPT | |
| SCHEMBL5129768 | 0.88 | GRM5 (0.54) | PKMCHRM2ALDH1A1L3MBTL1GRM5 | |
| SCHEMBL5124584 | 0.88 | PKM (0.47) | PKMLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5119674 | 0.85 | GRM5 (0.47) | PKMLMNAALDH1A1MEN1MAPT | |
| SCHEMBL5115048 | 0.84 | GRM5 (0.51) | ALDH1A1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL5119714 | 0.83 | GRM5 (0.45) | PKMLMNAALDH1A1MEN1MAPT | |
| SCHEMBL5124023 | 0.83 | SMN1; SMN2 (0.58) | ALDH1A1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL5122268 | 0.83 | ENPP2 (0.48) | PKMLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | GRM5, GRIK5, GRM1 | PKM 946/4885CHRM2 545/4885LMNA 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.