Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 9/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5117032 | 1.00 | HTT (0.47) | HTTHPGDL3MBTL1CYP3A4CYP11B2 | |
| SCHEMBL30996925 | 0.88 | HSD17B1 (0.57) | HTTHPGDL3MBTL1CYP3A4CYP11B2 | |
| SCHEMBL5123694 | 0.87 | HTT (0.51) | HTTHPGDL3MBTL1HSD17B1BRAF | |
| SCHEMBL5123691 | 0.87 | HTT (0.51) | HTTHPGDL3MBTL1HSD17B1BRAF | |
| SCHEMBL5118121 | 0.83 | HTT (0.61) | HTTHPGDL3MBTL1HSD17B1BRAF | |
| SCHEMBL5118128 | 0.83 | HTT (0.61) | HTTHPGDL3MBTL1HSD17B1BRAF | |
| SCHEMBL5116955 | 0.82 | PARP10 (0.50) | HTTHPGDL3MBTL1HRH3HSD17B1 | |
| SCHEMBL5116961 | 0.82 | PARP10 (0.50) | HTTHPGDL3MBTL1HRH3HSD17B1 | |
| SCHEMBL9488600 | 0.81 | HPGD (0.57) | HTTHPGDL3MBTL1HRH3HSD17B1 | |
| SCHEMBL5123716 | 0.79 | HTT (0.56) | HTTHPGDL3MBTL1HSD17B1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414142-B2 | 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators | WYETH (US) | 2008-08-19 | — | — | US | disclosed |
| US-20070066637-A1 | 5-Aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators | WYETH (US) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066637-A1 | 5-Aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators | CYP19A1, PGR, GNRHR | HTT 4288/4885HPGD 208/4885L3MBTL1 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.