SCHEMBL51173

SCHEMBL51173

Oc1cc(Cl)ccc1Cc1ccc(Cl)cc1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.67
MEN1 O00255 5/20 0.67
KMT2A Q03164 5/20 0.67
HPGD P15428 5/20 0.67
HIF1A Q16665 4/20 0.67
MAPT P10636 4/20 0.67
ALOX15 P16050 4/20 0.67
SMN1; SMN2 Q16637 3/20 0.67
HSPA5 P11021 3/20 0.67
HSP90AA1 P07900 3/20 0.67
ALOX12 P18054 2/20 0.67
IDO1 P14902 2/20 0.67
HTT P42858 2/20 0.67
USP2 O75604 2/20 0.67
CASP1 P29466 2/20 0.67
LMNA P02545 2/20 0.67
SLC22A1 O15245 1/20 0.67
HSPD1 P10809 1/20 0.67
BLM P54132 1/20 0.67
HSPE1 P61604 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10539465 0.91 CYP3A4 (0.63) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL11248603 0.91 MAPT (0.57) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL10764611 0.86 MEN1 (0.61) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL561006 0.83 CYP3A4 (0.52) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL8768625 0.82 MEN1 (0.74) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL28534044 0.81 CYP3A4 (0.50) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL18551328 0.81 HSD17B10 (0.50) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL1005910 0.81 HSD17B10 (0.50) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL16795136 0.81 SLC6A4 (0.53) CYP3A4MEN1KMT2AHPGDHIF1A
SCHEMBL11255184 0.80 MEN1 (0.59) CYP3A4MEN1KMT2AHPGDHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744833-B1 INHIBITOR COMPOSITIONS AND METHODS OF USE NUFARM UK LTD (GB) 2016-09-28 EP claimed
US-20140194559-A1 Novel Inhibitor Compositions and Methods of Use NUFARM UK LIMITED (GB) 2014-07-10 US claimed
EP-2744833-A1 NOVEL INHIBITOR COMPOSITIONS AND METHODS OF USE Nufarm UK Limited (GB) 2014-06-25 EP claimed
WO-2013027042-A1 NOVEL INHIBITOR COMPOSITIONS AND METHODS OF USE NUFARM UK LIMITED (GB) 2013-02-28 WO claimed
EP-2744833-B1 INHIBITOR COMPOSITIONS AND METHODS OF USE NUFARM UK LTD (GB) 2016-09-28 EP disclosed
EP-2181853-B1 Thermosensitive recording medium JUJO PAPER CO LTD (JP) 2015-09-23 EP disclosed
US-20140194559-A1 Novel Inhibitor Compositions and Methods of Use NUFARM UK LIMITED (GB) 2014-07-10 US disclosed
EP-2744833-A1 NOVEL INHIBITOR COMPOSITIONS AND METHODS OF USE Nufarm UK Limited (GB) 2014-06-25 EP disclosed
US-8497227-B2 Diphenylsulfone bridged compound, color forming substance for thermal recording and thermal recording material NICCA CHEMICAL CO., LTD. (JP) 2013-07-30 US disclosed
US-8492308-B2 Thermosensitive recording medium NIPPON PAPER INDUSTRIES CO., LTD. (JP) 2013-07-23 US disclosed
WO-2013027042-A1 NOVEL INHIBITOR COMPOSITIONS AND METHODS OF USE NUFARM UK LIMITED (GB) 2013-02-28 WO disclosed
US-8129307-B2 Thermosensitive recording medium NIPPON PAPER INDUSTRIES CO., LTD. (JP) 2012-03-06 US disclosed
US-7141359-B2 Developers for thermal recording materials and thermal recording materials API CORPORATION (JP) 2006-11-28 US disclosed
US-20050118526-A1 Developers for thermal recording materials and thermal recording materials MITSUBISHI CHEMICAL CORPORATION (JP) 2005-06-02 US disclosed
EP-1393923-A1 DEVELOPERS FOR THERMAL RECORDING MATERIALS AND THERMAL RECORDING MATERIALS API Corporation (JP) 2004-03-03 EP disclosed
EP-0589427-B1 Thermosensitive recording medium DAINIPPON INK & CHEMICALS (JP) 1997-03-12 EP disclosed
US-5518982-A SOLID SOLUTION, IMPROVED IMAGE STABILITY, PAPER FOR FACSIMILE, THERMAL PRINTING DAINIPPON INK AND CHEMICALS, INC. (JP) 1996-05-21 US disclosed
EP-0589427-A2 Thermosensitive recording medium DAINIPPON INK AND CHEMICALS, INC. (JP) 1994-03-30 EP disclosed
US-4810773-A HIGH MOLECULAR WEIGHT ENGINEERING THERMOPLASTICS IDEMITSU PETROCHEMICAL CO., LTD. (JP) 1989-03-07 US disclosed
EP-0215312-A1 Method for producing of polyarylene sulfides IDEMITSU PETROCHEMICAL CO. LTD. (JP) 1987-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140194559-A1 Novel Inhibitor Compositions and Methods of Use NQO1, NQO2, ABCG2 CYP3A4 177/4885MEN1 4390/4885KMT2A 2428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.