Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.40 |
| ▸ | CA9 | Q16790 | 13/20 | 0.40 |
| ▸ | CA1 | P00915 | 12/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3999601 | 0.80 | AURKA (0.52) | CA2CDK2CDK1KDRCCNB2 | |
| SCHEMBL14995676 | 0.80 | CA2 (0.51) | CA2CA9CA1CA12ENPP3 | |
| SCHEMBL14995680 | 0.73 | CA2 (0.45) | CA2CA9CA1CA12ENPP3 | |
| SCHEMBL4005363 | 0.73 | SYK (0.53) | CDK2CDK1KDRCCNB2CCNB1 | |
| SCHEMBL4005254 | 0.70 | SYK (0.61) | CDK2CDK1KDR | |
| SCHEMBL5029661 | 0.69 | ENPP3 (0.47) | CA2CA9CA1ENPP3MAPT | |
| SCHEMBL15651946 | 0.68 | ITGB1 (0.50) | — | |
| SCHEMBL18787383 | 0.66 | ADORA2A (0.46) | CA2CA9CA1CA12ENPP3 | |
| SCHEMBL3998901 | 0.63 | AURKA (0.58) | CA2CDK2CDK1KDRCCNB2 | |
| SCHEMBL3999767 | 0.63 | AURKA (0.55) | CA2CA1CA12CDK2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | disclosed |