Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.47 |
| ▸ | TUBB | P07437 | 6/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119935 | 0.88 | GAA (0.53) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL5127415 | 0.86 | SALL4 (0.59) | GAAMAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5121920 | 0.85 | ALDH1A1 (0.42) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL5114398 | 0.84 | BRD4 (0.46) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL5121825 | 0.84 | NR1H4 (0.47) | GAAMAPTALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL5123502 | 0.83 | BRD4 (0.45) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL5113507 | 0.82 | GAA (0.43) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL5120229 | 0.81 | CDK9 (0.50) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL5121816 | 0.81 | PKM (0.43) | GAAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL15452683 | 0.81 | GAA (0.69) | GAAMAPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791840-B1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2013-11-27 | — | — | EP | claimed |
| US-7420056-B2 | Substituted bicyclic imidazo-3-ylamine compounds | GRUENENTHAL GMBH (DE) | 2008-09-02 | — | — | US | claimed |
| US-20070155965-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | GRUENENTHAL GMBH. (DE) | 2007-07-05 | — | — | US | claimed |
| EP-1791840-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2007-06-06 | — | — | EP | claimed |
| WO-2006029980-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-23 | — | — | WO | claimed |
| US-7420056-B2 | Substituted bicyclic imidazo-3-ylamine compounds | GRUENENTHAL GMBH (DE) | 2008-09-02 | — | — | US | disclosed |
| US-20070155965-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | GRUENENTHAL GMBH. (DE) | 2007-07-05 | — | — | US | disclosed |
| EP-1791840-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029980-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155965-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | AADAC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PAICS | GAA 234/4885MAPT 707/4885ALDH1A1 2777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.