Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115592 | 0.91 | SMN1; SMN2 (0.38) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL5722583 | 0.91 | THRB (0.37) | THRATHRBMRGPRX4PTGDR2EPHX2 | |
| SCHEMBL4934946 | 0.88 | SMN1; SMN2 (0.41) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL4926820 | 0.86 | EGLN1 (0.38) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL5120197 | 0.86 | EGLN1 (0.38) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL4931752 | 0.86 | THRB (0.47) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL4357825 | 0.86 | THRA (0.40) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL5117653 | 0.85 | MEN1 (0.38) | MEN1KMT2ASMN1; SMN2THRATHRB | |
| SCHEMBL5110808 | 0.85 | SMN1; SMN2 (0.38) | EGLN1MEN1KMT2ASMN1; SMN2THRA | |
| SCHEMBL4932995 | 0.85 | THRB (0.39) | EGLN1MEN1KMT2ASMN1; SMN2THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004251-A1 | Novel Pharmaceutical Compositions Comprising Agonists of the Thyroid Receptor | KARO BIO AB (SE) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004251-A1 | Novel Pharmaceutical Compositions Comprising Agonists of the Thyroid Receptor | TSHR, TRHR, THRA | EGLN1 3052/4885MEN1 806/4885KMT2A 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.