Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | VHL | P40337 | 1/20 | 0.31 |
| ▸ | ELOC | Q15369 | 1/20 | 0.31 |
| ▸ | ELOB | Q15370 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740847 | 0.86 | NR1H2 (0.44) | NR1H2NR1H3PRSS1PRSS2PRSS3 | |
| SCHEMBL8836682 | 0.85 | NR1H2 (0.63) | NR1H2NR1H3 | |
| SCHEMBL7739084 | 0.85 | NR1H2 (0.53) | NR1H2NR1H3TSHRCA12CA1 | |
| SCHEMBL7738421 | 0.82 | NR1H2 (0.50) | NR1H2NR1H3LTA4HCA2 | |
| SCHEMBL7732401 | 0.81 | NR1H2 (0.51) | NR1H2NR1H3TSHR | |
| SCHEMBL10522173 | 0.80 | NR1H2 (0.59) | NR1H2NR1H3TSHRCA12CA1 | |
| SCHEMBL7732429 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3TSHR | |
| SCHEMBL31347674 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3 | |
| SCHEMBL7732393 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3TSHRCA2 | |
| SCHEMBL7740839 | 0.78 | NR1H2 (0.49) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429670-B2 | Synthesis of derivatives of ginkgolide C | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-09-30 | — | — | US | disclosed |
| US-20050119336-A1 | Synthesis of derivatives of ginkgolide C | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-06-02 | — | — | US | disclosed |
| WO-2005021496-A2 | SYNTHESIS OF DERIVATIVES OF GINKGOLIDE C | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2005-03-10 | — | — | WO | disclosed |
| US-6416861-B1 | COMBINATORIAL CHEMISTRY | NORTHWESTERN UNIVERSITY | 2002-07-09 | — | — | US | disclosed |
| WO-2000049022-A2 | ORGANOSILICON COMPOUNDS AND USES THEREOF | NORTHWESTERN UNIVERSITY (US) | 2000-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119336-A1 | Synthesis of derivatives of ginkgolide C | GLRB, GLRA3, GRK7 | NR1H2 372/4885NR1H3 327/4885TSHR 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.