Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121491 | 0.90 | VHL (0.41) | TLR2TLR1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL5128379 | 0.90 | RXFP1 (0.41) | PTGER4MEN1KMT2A | |
| SCHEMBL5114844 | 0.87 | PTGER4 (0.39) | TLR2TLR1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL6645368 | 0.86 | LMNA (0.41) | TLR2TLR1PTGER4ALDH1A1L3MBTL1 | |
| SCHEMBL5122193 | 0.86 | LMNA (0.41) | TLR2TLR1PTGER4ALDH1A1L3MBTL1 | |
| SCHEMBL5121553 | 0.86 | ALDH1A1 (0.48) | PTGER4SMN1; SMN2ALDH1A1KCNH2CYP2C9 | |
| SCHEMBL5122404 | 0.85 | SMN1; SMN2 (0.41) | PTGER4SMN1; SMN2ALDH1A1KCNE1CCR1 | |
| SCHEMBL5119825 | 0.85 | ALDH1A1 (0.46) | PTGER4ALDH1A1KCNH2CYP2C9 | |
| SCHEMBL5123537 | 0.84 | PRKAA2 (0.41) | TLR2TLR1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL5123260 | 0.83 | KMT2A (0.42) | PTGER4SMN1; SMN2ALDH1A1ERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459452-B2 | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-12-02 | — | — | US | claimed |