Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.50 |
| ▸ | RBP4 | P02753 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5126853 | 0.92 | SMN1; SMN2 (0.51) | KDM4EGAATRPV1TRPA1HSD11B1 | |
| SCHEMBL5115293 | 0.92 | TRPV1 (0.51) | KDM4ETRPV1RBP4NPSR1HSD17B10 | |
| SCHEMBL5120186 | 0.91 | KDM4E (0.52) | KDM4ETRPV1RBP4TRPA1KCNH2 | |
| SCHEMBL5111504 | 0.90 | TRPV1 (0.48) | KDM4ETRPV1RBP4TRPA1KCNH2 | |
| SCHEMBL1457626 | 0.89 | TRPA1 (0.45) | KDM4EGAATRPV1RBP4TRPA1 | |
| SCHEMBL5112229 | 0.89 | RBP4 (0.47) | KDM4ETRPV1RBP4TRPA1KCNH2 | |
| SCHEMBL5112268 | 0.88 | RBP4 (0.47) | KDM4ETRPV1RBP4TRPA1KCNH2 | |
| SCHEMBL1457262 | 0.88 | TRPA1 (0.42) | KDM4EGAATRPV1RBP4TRPA1 | |
| SCHEMBL5125611 | 0.88 | TRPV1 (0.48) | KDM4ETRPV1RBP4TRPA1KCNH2 | |
| SCHEMBL5126475 | 0.88 | TRPV1 (0.48) | TRPV1RBP4TRPA1KCNH2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | claimed |
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | REN, PKD1, NR3C2 | KDM4E 3418/4885GAA 1971/4885TRPV1 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.