Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.50 |
| ▸ | ATF1 | P18846 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 6/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.47 |
| ▸ | RELA | Q04206 | 6/20 | 0.47 |
| ▸ | FOS | P01100 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536080 | 0.88 | FOS (0.59) | ALDH1A1KDM4ENFKB1SMN1; SMN2MAPT | |
| SCHEMBL5126930 | 0.87 | KDM4E (0.49) | ALDH1A1KDM4ENFKB1ATF1SMN1; SMN2 | |
| SCHEMBL12929531 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4ENFKB1ATF1SMN1; SMN2 | |
| SCHEMBL5119467 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KDM4ENFKB1SMN1; SMN2MAPT | |
| SCHEMBL5126330 | 0.81 | CYP1A2 (0.59) | ALDH1A1KDM4ENFKB1ATF1SMN1; SMN2 | |
| SCHEMBL5120286 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4ENFKB1SMN1; SMN2MAPT | |
| SCHEMBL5126291 | 0.81 | CYP1A2 (0.56) | ALDH1A1KDM4ENFKB1ATF1SMN1; SMN2 | |
| SCHEMBL23574436 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KDM4ENFKB1SMN1; SMN2MAPT | |
| SCHEMBL2087835 | 0.79 | ALDH1A1 (0.74) | ALDH1A1KDM4ENFKB1SMN1; SMN2MAPT | |
| SCHEMBL4951430 | 0.79 | CYP1A2 (0.64) | ALDH1A1KDM4ENFKB1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | DPYD, TYMP, TYMS | ALDH1A1 489/4885KDM4E 3188/4885NFKB1 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.