Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.48 |
| ▸ | FOS | P01100 | 3/20 | 0.48 |
| ▸ | JUN | P05412 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATF1 | P18846 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8395412 | 0.88 | FOS (0.60) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5118532 | 0.87 | ALDH1A1 (0.55) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12929531 | 0.85 | ALDH1A1 (0.66) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5114768 | 0.82 | ALDH1A1 (0.50) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5280707 | 0.81 | KMT2A (0.40) | KDM4EMAPTALDH1A1NFKB1FOS | |
| SCHEMBL5126871 | 0.81 | ALDH1A1 (0.46) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11785304 | 0.78 | ALDH1A1 (0.60) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4849077 | 0.78 | ALDH1A1 (0.76) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4181661 | 0.78 | ALDH1A1 (0.51) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5126330 | 0.78 | CYP1A2 (0.59) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | DPYD, TYMP, TYMS | KDM4E 3188/4885MAPT 4222/4885ALDH1A1 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.