Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121780 | 0.91 | GRM5 (0.41) | GRM5ALDH1A1MAP3K14MAOBHTR6 | |
| SCHEMBL5129798 | 0.91 | GRM5 (0.43) | GRM5MAP3K14 | |
| SCHEMBL5119696 | 0.89 | ALDH1A1 (0.50) | GRM5ALDH1A1 | |
| SCHEMBL5114539 | 0.88 | ADRB1 (0.46) | GRM5ALDH1A1 | |
| SCHEMBL5129125 | 0.86 | GRM5 (0.43) | GRM5ALDH1A1MAP3K14PTGES | |
| SCHEMBL5129376 | 0.85 | GRM5 (0.46) | GRM5MAP3K14 | |
| SCHEMBL5128709 | 0.84 | GRM5 (0.43) | GRM5MAP3K14PTGESPTPN11 | |
| SCHEMBL5114711 | 0.84 | GRM5 (0.46) | GRM5MAP3K14PTGES | |
| SCHEMBL5129624 | 0.83 | GRM5 (0.45) | GRM5MAP3K14HTR6PTGES | |
| SCHEMBL5118315 | 0.83 | HTR3E (0.45) | GRM5ALDH1A1MAP3K14PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | GRM5, GRIK5, GRM1 | GRM5 1/4885ALDH1A1 908/4885MAP3K14 2105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.