Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120569 | 1.00 | ACE (0.41) | ACECDK9CCNT1PPARGFPR2 | |
| SCHEMBL2821082 | 0.82 | ACE (0.38) | ACECDK9CCNT1PPARGPSEN1 | |
| SCHEMBL2822394 | 0.79 | MTNR1A (0.56) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2980372 | 0.79 | MTNR1A (0.56) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4738196 | 0.79 | MTNR1A (0.56) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5127042 | 0.78 | PSEN1 (0.55) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5131682 | 0.78 | DRD2 (0.49) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5131679 | 0.78 | DRD2 (0.49) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5127039 | 0.78 | PSEN1 (0.55) | ACEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5119348 | 0.78 | PSEN1 (0.43) | ACEPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384968-B2 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2008-06-10 | — | — | US | claimed |
| EP-1735292-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-12-27 | — | — | EP | claimed |
| US-20060084689-A1 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. | 2006-04-20 | — | — | US | claimed |
| WO-2005095367-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |
| US-20080207712-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. | 2008-08-28 | — | — | US | disclosed |
| US-7384968-B2 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1735292-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| US-20060084689-A1 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC. | 2006-04-20 | — | — | US | disclosed |
| WO-2005095367-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207712-A1 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | APP, PSEN1, BACE1 | ACE 927/4885CDK9 2274/4885CCNT1 697/4885 |
| US-20060084689-A1 | Thiazole-amine compounds for the treatment of neurodegenerative disorders | APP, PSEN1, BACE1 | ACE 927/4885CDK9 2274/4885CCNT1 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.