Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466627 | 0.87 | DYRK1A (0.49) | AKR1B1DYRK1ATRPV1KDM4APDPK1 | |
| SCHEMBL21954259 | 0.87 | DYRK1A (0.49) | AKR1B1DYRK1ATRPV1KDM4APDPK1 | |
| SCHEMBL24962455 | 0.86 | AKR1B1 (0.55) | AKR1B1DYRK1ATRPV1AKR1A1 | |
| SCHEMBL20509355 | 0.86 | DYRK1A (0.48) | AKR1B1DYRK1ATRPV1HDAC6KDM4A | |
| SCHEMBL24962449 | 0.86 | HDAC6 (0.52) | AKR1B1DYRK1ATRPV1HDAC6 | |
| SCHEMBL30466621 | 0.86 | DYRK1A (0.48) | AKR1B1DYRK1ATRPV1HDAC6KDM4A | |
| SCHEMBL24962469 | 0.84 | DYRK1A (0.47) | AKR1B1DYRK1ATRPV1HDAC6KDM4A | |
| SCHEMBL24963248 | 0.83 | PPARA (0.49) | DYRK1ATRPV1KDM4APDPK1 | |
| SCHEMBL30493007 | 0.83 | DYRK1A (0.48) | AKR1B1DYRK1ATRPV1GRM2KDM4A | |
| SCHEMBL28366491 | 0.83 | DYRK1A (0.48) | AKR1B1DYRK1ATRPV1GRM2KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207683-A1 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207683-A1 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | AKR1B1 2685/4885DYRK1A 2708/4885TRPV1 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.