SCHEMBL5125589

SCHEMBL5125589

CC(=O)Nc1cc2c3c(cccc3c1)C(=O)N(CC(=O)Oc1c(F)c(F)c(F)c(F)c1F)C2=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 1/20 0.51
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
POLB P06746 1/20 0.45
FTO Q9C0B1 1/20 0.44
MAPT P10636 3/20 0.43
KDM4E B2RXH2 3/20 0.43
ALDH1A1 P00352 3/20 0.43
ALOX15 P16050 2/20 0.43
CYP1A2 P05177 1/20 0.43
AKR1B1 P15121 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
LMNA P02545 1/20 0.42
G6PD P11413 1/20 0.42
ALOX12 P18054 1/20 0.42
MPI P34949 1/20 0.42
HTT P42858 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TYMS P04818 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5127095 0.84 MEN1 (0.59) MEN1KMT2APOLBMAPTKDM4E
SCHEMBL5123962 0.82 KDM4E (0.64) KLK7MEN1KMT2AFTOMAPT
SCHEMBL5123577 0.80 FTO (0.57) MEN1KMT2APOLBFTOMAPT
SCHEMBL7709436 0.77 KLK7 (0.61) KLK7MEN1KMT2AFTOMAPT
SCHEMBL14557208 0.76 KLK7 (0.57) KLK7MEN1KMT2APOLBFTO
SCHEMBL20591966 0.76 KMT2A (0.71) MEN1KMT2APOLBMAPTKDM4E
SCHEMBL11440392 0.75 FTO (0.71) KLK7MEN1KMT2APOLBFTO
SCHEMBL5160041 0.74 KLK7 (0.55) KLK7MEN1KMT2APOLBFTO
SCHEMBL8395426 0.74 SIRT1 (0.65) KLK7FTOMAPTALDH1A1CYP1A2
SCHEMBL3851575 0.74 KMT2A (0.67) KLK7MEN1KMT2APOLBFTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080138817-A1 Novel Functional Peptide Nucleic Acid Monomer and Process for Producing the Same CREDIA JAPAN CO., LTD. (JP) 2008-06-12 US disclosed
US-7282575-B2 Functional peptide nucleic acid monomer and process for producing the same CREDIA JAPAN CO., LTD. (JP) 2007-10-16 US disclosed
US-20040101839-A1 Novel functional peptide nucleic acid monomer and process for producing the same CREDIA JAPAN CO., LTD. (JP) 2004-05-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040101839-A1 Novel functional peptide nucleic acid monomer and process for producing the same NSUN3, NSUN2, RNGTT KLK7 3498/4885MEN1 1593/4885KMT2A 2193/4885
US-20080138817-A1 Novel Functional Peptide Nucleic Acid Monomer and Process for Producing the Same NSUN3, RNGTT, NSUN2 KLK7 4445/4885MEN1 3066/4885KMT2A 2806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.