Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formamide SCHEMBL5117411 | 0.94 | HTT (0.44) | SMN1; SMN2HTTNPSR1CA1CA2 | |
| Formamide SCHEMBL5118917 | 0.93 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTNPSR1CYP2C9CYP2C19 | |
| Formamide SCHEMBL5115801 | 0.83 | CXCR3 (0.47) | — | |
| Formamide SCHEMBL5112955 | 0.79 | GFER (0.47) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL1457198 | 0.79 | NAMPT (0.48) | CA1CA2CA9MAPTALDH1A1 | |
| SCHEMBL5115334 | 0.79 | ALDH1A1 (0.45) | SMN1; SMN2NPSR1CYP2C9CYP2C19MAPT | |
| Formamide SCHEMBL5126269 | 0.79 | NPC1 (0.44) | SMN1; SMN2MAPTALDH1A1HPGDLMNA | |
| Hydrochloric Acid SCHEMBL5116601 | 0.78 | HPGD (0.44) | SMN1; SMN2NPSR1CYP2C9CYP2C19MAPT | |
| SCHEMBL5122782 | 0.78 | MEN1 (0.47) | SMN1; SMN2HTTMAPTALDH1A1LMNA | |
| SCHEMBL5114594 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2HTTNPSR1CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | claimed |
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | REN, PKD1, NR3C2 | SMN1; SMN2 4677/4885HTT 1428/4885NPSR1 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.