Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485267 | 0.85 | PDPK1 (0.53) | PDPK1PARP1PARP10PARP11KMT2A | |
| SCHEMBL6485264 | 0.85 | PDPK1 (0.53) | PDPK1PARP1PARP10PARP11KMT2A | |
| SCHEMBL6485271 | 0.85 | PDPK1 (0.53) | PDPK1PARP1PARP10PARP11KMT2A | |
| SCHEMBL14279596 | 0.80 | PDPK1 (0.47) | PDPK1PARP1PARP10PARP11KMT2A | |
| SCHEMBL2552644 | 0.74 | PARP10 (0.56) | PDPK1PARP1PARP10PARP11TUBB4A | |
| SCHEMBL9391477 | 0.74 | CES1 (0.45) | HTTNOTUMSMN1; SMN2CES1SRD5A1 | |
| SCHEMBL9391470 | 0.74 | CES1 (0.45) | HTTNOTUMSMN1; SMN2CES1SRD5A1 | |
| SCHEMBL9391471 | 0.74 | CES1 (0.45) | HTTNOTUMSMN1; SMN2CES1SRD5A1 | |
| SCHEMBL13808059 | 0.72 | MAPT (0.71) | KMT2AMEN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL8780459 | 0.71 | RXRA (0.56) | KMT2AMEN1LMNANOTUMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302533-A1 | DERIVATIVES OF PYRIMIDO [6,1-A] ISOQUINOLIN-4-ONE | VERONA PHARMA PLC (GB) | 2012-11-29 | — | — | US | disclosed |
| US-8242127-B2 | INHIBITORS OF PHOSPHODIESTERASE (PDE) ISOENZYMES; USEFUL FOR TREATMENT OF RESPIRATORY DISORDERS SUCH AS ASTHMA; chronic obstructive pulmonary disease (COPD); 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2012-08-14 | — | — | US | disclosed |
| US-20080206163-A1 | Derivatives of pyrimido[6, 1-A]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2008-08-28 | — | — | US | disclosed |
| US-7378424-B2 | Derivatives of pyrimido[6, 1-A]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2008-05-27 | — | — | US | disclosed |
| US-7105663-B2 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | RHINOPHARMA LIMITED (CA) | 2006-09-12 | — | — | US | disclosed |
| US-6794391-B2 | INHIBITORS OF PHOSPHODIESTERASE (PDE) ISOENZYMES; USEFUL FOR TREATMENT OF RESPIRATORY DISORDERS SUCH AS ASTHMA. | VERNALIS LIMITED (GB) | 2004-09-21 | — | — | US | disclosed |
| US-20040176353-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED | 2004-09-09 | — | — | US | disclosed |
| US-20040171828-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED | 2004-09-02 | — | — | US | disclosed |
| EP-1165558-B1 | DERIVATIVES OF PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE | VERNALIS LTD (GB) | 2003-09-24 | — | — | EP | disclosed |
| US-20030036542-A1 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one | VERONA PHARMA PLC (GB) | 2003-02-20 | — | — | US | disclosed |
| EP-1165558-A1 | DERIVATIVES OF PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE | Vernalis Limited (GB) | 2002-01-02 | — | — | EP | disclosed |
| EP-1165556-A1 | DERIVATIVES OF PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE | Vernalis Limited (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058309-A1 | DERIVATIVES OF PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE | VERNALIS LIMITED (GB) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000058308-A1 | DERIVATIVES OF PYRIMIDO[6,1-a]ISOQUINOLIN-4-ONE | VERNALIS LIMITED (GB) | 2000-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302533-A1 | DERIVATIVES OF PYRIMIDO [6,1-A] ISOQUINOLIN-4-ONE | PDE4A, PDE2A, PDE12 | PDPK1 998/4885PARP1 277/4885PARP10 869/4885 |
| US-20030036542-A1 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one | CXCR6, HRH1, HRH2 | PDPK1 4111/4885PARP1 934/4885PARP10 1607/4885 |
| US-20040176353-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | TAS1R2, TAS2R1, TAS2R7 | PDPK1 3557/4885PARP1 1487/4885PARP10 1960/4885 |
| US-20040171828-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | TAS2R1, TAS2R7, TAS2R50 | PDPK1 3913/4885PARP1 1716/4885PARP10 2059/4885 |
| US-20080206163-A1 | Derivatives of pyrimido[6, 1-A]isoquinolin-4-one | HRH2, HRH4, TAS2R3 | PDPK1 4279/4885PARP1 2579/4885PARP10 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.