Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 19/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115998 | 0.92 | SLC6A4 (0.87) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL5872393 | 0.87 | SLC6A2 (0.59) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL5872404 | 0.86 | SLC6A2 (0.60) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL27641058 | 0.86 | SLC6A4 (0.55) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL5123815 | 0.86 | SLC6A4 (0.55) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL4489486 | 0.84 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL4498817 | 0.79 | SLC6A4 (0.87) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL4487890 | 0.79 | SLC6A4 (0.87) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL5121849 | 0.79 | SLC6A4 (0.78) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL5925414 | 0.79 | SLC6A4 (0.78) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432280-B2 | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2008-10-07 | — | — | US | disclosed |
| US-20070105960-A1 | Treatment of learning disabilities and motor skills disorder with norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2007-05-10 | — | — | US | disclosed |
| US-20070066663-A1 | 3-Aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2007-03-22 | — | — | US | disclosed |
| US-20070032554-A1 | Treatment of stuttering and other communication disorders with norepinephrine reuptake inhibitors | ELILILLY AND COMPANY A CORPORATION | 2007-02-08 | — | — | US | disclosed |
| US-20070015786-A1 | Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition | ELI LILY AND COMPANY (US) | 2007-01-18 | — | — | US | disclosed |
| US-20060241188-A1 | Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors | ELILILLY AND COMPANY (US) | 2006-10-26 | — | — | US | disclosed |
| EP-1638560-A1 | 3-AMINOPIPERIDINES AND 3-AMINOQUINUCLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000305-A1 | 3-AMINOPIPERIDINES AND 3-AMINOQUINUCLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241188-A1 | Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors | SLC6A2, SLC6A3, SLC6A4 | SLC6A2 1/4885SLC6A4 3/4885CYP2D6 231/4885 |
| US-20070105960-A1 | Treatment of learning disabilities and motor skills disorder with norepinephrine reuptake inhibitors | SLC6A2, SLC6A3, SLC6A4 | SLC6A2 1/4885SLC6A4 3/4885CYP2D6 945/4885 |
| US-20070032554-A1 | Treatment of stuttering and other communication disorders with norepinephrine reuptake inhibitors | SLC6A2, SLC6A4, SLC6A3 | SLC6A2 1/4885SLC6A4 2/4885CYP2D6 1256/4885 |
| US-20070015786-A1 | Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition | SLC6A2, SLC6A4, HTR5A | SLC6A2 1/4885SLC6A4 2/4885CYP2D6 608/4885 |
| US-20070066663-A1 | 3-Aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake | SLC6A2, SLC6A3, SLC18A1 | SLC6A2 1/4885SLC6A4 6/4885CYP2D6 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.