Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 18/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5131752 | 0.89 | CTSS (0.44) | CTSSKCNK3 | |
| SCHEMBL5130890 | 0.89 | CTSS (0.63) | CTSS | |
| SCHEMBL5131616 | 0.88 | CTSS (0.46) | CTSSKCNK3BRD4CREBBP | |
| SCHEMBL5123995 | 0.85 | CTSS (0.44) | CTSSKCNK3CREBBP | |
| SCHEMBL2969873 | 0.82 | CTSS (0.61) | CTSSKCNK3BRD4CREBBP | |
| SCHEMBL5131262 | 0.82 | CTSS (0.55) | CTSS | |
| SCHEMBL5131266 | 0.82 | CTSS (0.55) | CTSS | |
| SCHEMBL2980722 | 0.76 | CTSS (0.47) | CTSSKCNK3CREBBP | |
| SCHEMBL4030200 | 0.76 | MAPK1 (0.48) | BRD4CREBBP | |
| SCHEMBL2978891 | 0.75 | CTSS (0.53) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | CTSS 1/4885KCNK3 2242/4885BRD4 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.