Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925320 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3DPP4FAP | |
| SCHEMBL5112330 | 0.79 | SLC6A2 (0.42) | SLC6A2SLC6A4KDM4EALDH1A1MAPT | |
| SCHEMBL6264470 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1MAPTTACR1DPP4 | |
| SCHEMBL5120703 | 0.77 | SLC6A2 (0.60) | SLC6A2SLC6A4KDM4EALDH1A1MAPT | |
| SCHEMBL4487295 | 0.76 | SLC6A4 (0.39) | SLC6A2SLC6A4KDM4ETACR1SLC6A3 | |
| SCHEMBL5887848 | 0.73 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4687367 | 0.73 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL5232639 | 0.73 | SLC6A2 (0.49) | SLC6A2SLC6A4KDM4EALDH1A1SLC6A3 | |
| SCHEMBL5696046 | 0.72 | SIGMAR1 (0.45) | KDM4EALDH1A1MAPTTACR1ATM | |
| SCHEMBL5996568 | 0.72 | SLC6A2 (0.55) | SLC6A2SLC6A4KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432280-B2 | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2008-10-07 | — | — | US | disclosed |
| US-20070066663-A1 | 3-Aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2007-03-22 | — | — | US | disclosed |
| US-20060241188-A1 | Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors | ELILILLY AND COMPANY (US) | 2006-10-26 | — | — | US | disclosed |
| WO-2005053663-A2 | NOREPINEPHRINE REUPTAKE INHIBITORS USEFUL FOR TREATMENT OF COGNITIVE FAILURE | ELI LILLY AND COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241188-A1 | Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors | SLC6A2, SLC6A3, SLC6A4 | SLC6A2 1/4885SLC6A4 3/4885KDM4E 392/4885 |
| US-20070066663-A1 | 3-Aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake | SLC6A2, SLC6A3, SLC18A1 | SLC6A2 1/4885SLC6A4 6/4885KDM4E 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.