Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5131567 | 0.89 | KMT2A (0.43) | GAAKDM4EALDH1A1SIGMAR1MEN1 | |
| SCHEMBL1033166 | 0.83 | L3MBTL1 (0.57) | L3MBTL1KDM4ERECQLADRB2ALDH1A1 | |
| SCHEMBL7235032 | 0.81 | GAA (0.65) | GAAKDM4EADRB2SIGMAR1KCNH2 | |
| SCHEMBL198568 | 0.80 | NR3C1 (0.36) | KDM4EADRB2 | |
| SCHEMBL28152391 | 0.80 | GAA (0.42) | GAAL3MBTL1KDM4ERECQLADRB2 | |
| SCHEMBL29602871 | 0.78 | TAAR1 (0.55) | GAAL3MBTL1KDM4ERECQLALDH1A1 | |
| SCHEMBL14566080 | 0.78 | TAAR1 (0.55) | L3MBTL1KDM4EALDH1A1KCNH2KMT2A | |
| SCHEMBL28291658 | 0.76 | SIGMAR1 (0.41) | GAAL3MBTL1SIGMAR1 | |
| SCHEMBL7003569 | 0.76 | IDO1 (0.38) | L3MBTL1KDM4EALDH1A1PKMKCNH2 | |
| SCHEMBL7002413 | 0.75 | L3MBTL1 (0.37) | L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020203-A1 | PYRIDINYLQUINAZ0LINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |