Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132309 | 0.98 | OPRM1 (0.44) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5123805 | 0.91 | OPRM1 (0.43) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5127145 | 0.89 | OPRM1 (0.46) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5131080 | 0.89 | SIGMAR1 (0.46) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5128658 | 0.88 | OPRM1 (0.45) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL14411784 | 0.88 | MEN1 (0.44) | DRD2DRD4DRD3BDKRB1 | |
| SCHEMBL5128604 | 0.87 | SIGMAR1 (0.47) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5123838 | 0.87 | MEN1 (0.42) | OPRM1OPRL1OPRD1OPRK1BDKRB1 | |
| SCHEMBL5126207 | 0.87 | OPRM1 (0.47) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5131363 | 0.86 | OPRM1 (0.47) | SIGMAR1OPRM1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249128-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-10-09 | — | — | US | claimed |
| US-8580965-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-20080249128-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249128-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, NPSR1 | SIGMAR1 108/4885OPRM1 232/4885OPRL1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.