Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 9/20 | 0.61 |
| ▸ | GRM5 | P41594 | 9/20 | 0.61 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975585 | 0.79 | GRM1 (0.60) | GRM1GRM5GPR119HTTATM | |
| SCHEMBL1473227 | 0.78 | GPR119 (0.51) | GRM1GRM5GPR119 | |
| SCHEMBL15051069 | 0.78 | GPR119 (0.53) | GRM1GRM5GPR119NPC1 | |
| SCHEMBL513799 | 0.78 | GPR119 (0.47) | GRM1GRM5GPR119 | |
| SCHEMBL8614193 | 0.76 | GRM1 (0.60) | GRM1GRM5GPR119 | |
| SCHEMBL8614176 | 0.76 | GRM1 (1.00) | GRM1GRM5GPR119 | |
| SCHEMBL30118966 | 0.76 | GRM5 (0.49) | GRM1GRM5GPR119 | |
| SCHEMBL7507003 | 0.75 | GRM5 (0.48) | GRM5GPR119HTT | |
| SCHEMBL15057408 | 0.74 | GPR119 (0.47) | GRM1GRM5GPR119 | |
| SCHEMBL18280165 | 0.74 | USP30 (0.47) | GRM5GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | GRM1 6/4885GRM5 2/4885GPR119 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.