SCHEMBL512860

SCHEMBL512860

Cc1cccc(C(=O)Cl)n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.59
P2RX7 Q99572 1/20 0.58
RAB9A P51151 2/20 0.47
CCR1 P32246 1/20 0.44
CCR8 P51685 1/20 0.44
KDM4E B2RXH2 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
ACMSD Q8TDX5 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MAPT P10636 1/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
POLB P06746 1/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CYP1A2 P05177 1/20 0.42
NOS3 P29474 1/20 0.41
NOS2 P35228 1/20 0.41
FPR2 P25090 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29502527 1.00 GRM5 (0.59) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL321127 0.84 KDM4E (0.59) GRM5RAB9AKDM4EALOX15TSHR
SCHEMBL2237588 0.82 P2RX7 (0.62) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL1958309 0.82 P2RX7 (0.62) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL118409 0.80 KDM4E (0.70) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL247491 0.80 P2RX7 (0.60) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL9937722 0.80 P2RX7 (0.60) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL29590328 0.80 P2RX7 (0.60) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL1013960 0.78 P2RX7 (0.63) GRM5P2RX7RAB9ACCR1CCR8
SCHEMBL9958643 0.78 P2RX7 (0.58) GRM5P2RX7RAB9ACCR1CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2026-02-12 US disclosed
US-12545659-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-02-10 US disclosed
US-12539295-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-02-03 US disclosed
US-20250320234-A1 LONP1 INHIBITOR COMPOUNDS, USES AND METHODS PRETZEL THERAPEUTICS, INC. (US) 2025-10-16 US disclosed
US-20240417379-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2024-12-19 US disclosed
EP-4444728-A1 LONP1 INHIBITOR COMPOUNDS, USES AND METHODS Pretzel Therapeutics, Inc. (US) 2024-10-16 EP disclosed
US-12116351-B2 P2X4 receptor antagonist NIPPON CHEMIPHAR CO., LTD (JP) 2024-10-15 US disclosed
US-20240131016-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-04-25 US disclosed
US-20240059674-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-02-22 US disclosed
US-11779578-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-10-10 US disclosed
EP-1966184-B1 PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE NEUROSEARCH AS (DK) 2010-08-25 EP disclosed
US-20090306102-A1 2-PYRIDIN-2-YL-QUINAZOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATING AGENTS FOR THE TREATMENT OF RESPIRATORY DISEASES NEUROSEARCH A/S (DK) 2009-12-10 US disclosed
EP-1966184-A2 PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE NeuroSearch A/S (DK) 2008-09-10 EP disclosed
WO-2008099020-A1 1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS TIBOTEC PHARMACEUTICALS LTD. (IE) 2008-08-21 WO disclosed
WO-2008099020-A1 1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS TIBOTEC PHARMACEUTICALS LTD. (IE) 2008-08-21 WO disclosed
WO-2007071632-A2 2-PYRIDIN-2-YL-QUINAZOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATING AGENTS FOR THE TREATMENT OF RESPIRATORY DISEASES NEUROSEARCH A/S (DK) 2007-06-28 WO disclosed
US-4701461-A ANTIALLERGENS USV PHARMACEUTICAL CORPORATION (US) 1987-10-20 US disclosed
US-4632929-A CARDIOTONIC AGENTS, ANTIALLERGENS USV PHARMACEUTICAL CORP. (US) 1986-12-30 US disclosed
US-4569941-A Method of using phenyl-alkylene-2-pyridyl derivatives to increase cardiac contractility in a mammal USV PHARMACEUTICAL CORP. (US) 1986-02-11 US disclosed
US-4267174-A AND PROCESS FOR ADMINISTERING BOEHRINGER MANNHEIM, GMBH (DE) 1981-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12545659-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK4 GRM5 665/4885P2RX7 3982/4885RAB9A 4491/4885
US-20250320234-A1 LONP1 INHIBITOR COMPOUNDS, USES AND METHODS LONP1, NLN, ACAT1 GRM5 3702/4885P2RX7 2775/4885RAB9A 1433/4885
US-20240417379-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 GRM5 273/4885P2RX7 1/4885RAB9A 3264/4885
US-12116351-B2 P2X4 receptor antagonist P2RX7, P2RX1, P2RX2 GRM5 165/4885P2RX7 1/4885RAB9A 3462/4885
US-12539295-B2 IRAK degraders and uses thereof IRAK2, IRAK4, IRAK3 GRM5 786/4885P2RX7 1652/4885RAB9A 4538/4885
US-20240131016-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 GRM5 2626/4885P2RX7 1103/4885RAB9A 4270/4885
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK4 GRM5 1693/4885P2RX7 1935/4885RAB9A 4525/4885
US-20240059674-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 GRM5 2626/4885P2RX7 1103/4885RAB9A 4270/4885
US-11779578-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 GRM5 2626/4885P2RX7 1103/4885RAB9A 4270/4885
US-20090306102-A1 2-PYRIDIN-2-YL-QUINAZOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATING AGENTS FOR THE TREATMENT OF RESPIRATORY DISEASES KCNJ2, KCNQ1, KCNK2 GRM5 800/4885P2RX7 121/4885RAB9A 1695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.