Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPR1 | P16066 | 5/20 | 0.35 |
| ▸ | NPR3 | P17342 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 6/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127968 | 0.84 | CNR1 (0.35) | — | |
| SCHEMBL3334512 | 0.81 | ABL1 (0.42) | NPR1ABL1ATMRIPK1 | |
| SCHEMBL3334949 | 0.80 | BRAF (0.43) | MOKNAMPT | |
| SCHEMBL3334852 | 0.80 | MAPK14 (0.41) | MALT1MAPK1NAMPT | |
| SCHEMBL3336288 | 0.79 | MOK (0.47) | MALT1MOKATM | |
| SCHEMBL5127946 | 0.78 | ACHE (0.37) | RIPK1 | |
| SCHEMBL3335966 | 0.77 | ADORA3 (0.40) | NPR1MAPK1NAMPT | |
| SCHEMBL3338081 | 0.76 | BRAF (0.46) | — | |
| SCHEMBL5131738 | 0.73 | PDGFRB (0.45) | MOK | |
| SCHEMBL3335706 | 0.72 | NAMPT (0.42) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |