Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5130188 | 0.98 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL5123709 | 0.95 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL1172369 | 0.95 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL2712653 | 0.91 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| Formaldehyde SCHEMBL19406154 | 0.88 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL4439983 | 0.87 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL4441473 | 0.86 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL5132635 | 0.86 | SIRT6 (0.62) | MAPTALDH1A1SMN1; SMN2PKMMEN1 | |
| SCHEMBL2712073 | 0.85 | SLC6A9 (0.50) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL4430482 | 0.84 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | EPHB4, EPHB1, NME2 | MAPT 3593/4885ALDH1A1 1143/4885SMN1; SMN2 3746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.