Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | LIPC | P11150 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140172 | 0.98 | GABRA5 (0.35) | HPGDGABRA5JAK1LIPCALDH1A1 | |
| SCHEMBL5131336 | 0.94 | GABRA5 (0.36) | HPGDGABRA5JAK1LIPCALDH1A1 | |
| SCHEMBL3331181 | 0.91 | DPP4 (0.37) | HPGDGABRA5JAK1S1PR1S1PR3 | |
| SCHEMBL3338041 | 0.90 | HPGD (0.40) | HPGDGABRA5JAK1ALDH1A1HSD17B10 | |
| SCHEMBL3335512 | 0.86 | DPP4 (0.38) | HPGDGABRA5JAK1S1PR1S1PR3 | |
| SCHEMBL3335323 | 0.85 | ALDH1A1 (0.40) | ALDH1A1CYP3A4TSHRHSD17B10S1PR1 | |
| SCHEMBL3337282 | 0.83 | MGLL (0.41) | HPGDGABRA5JAK1ALDH1A1HSD17B10 | |
| SCHEMBL3336025 | 0.81 | HPGD (0.45) | HPGD | |
| SCHEMBL3333969 | 0.81 | HPGD (0.43) | HPGDJAK1ALDH1A1HSD17B10MGLL | |
| SCHEMBL3341492 | 0.80 | ALDH1A1 (0.39) | ALDH1A1CYP3A4TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |