Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306942 | 1.00 | HTR2C (0.45) | HTR2CDDB1CRBNPKMTNKS2 | |
| SCHEMBL9903703 | 0.89 | HTR2C (0.49) | HTR2CDDB1CRBNPKMPBRM1 | |
| SCHEMBL13394483 | 0.83 | PKM (0.50) | HTR2CDDB1CRBNPKMTNKS2 | |
| SCHEMBL5125493 | 0.80 | HTR2C (0.49) | HTR2CPKMHTR1ASLC6A2SLC6A4 | |
| SCHEMBL4310679 | 0.80 | HTR2C (0.49) | HTR2CPKMHTR1ASLC6A2SLC6A4 | |
| SCHEMBL1705219 | 0.76 | MAOB (0.42) | ALDH1A1USP2HPGDHSD17B10 | |
| SCHEMBL13950143 | 0.76 | MAOB (0.42) | ALDH1A1USP2HPGDHSD17B10 | |
| SCHEMBL14521456 | 0.76 | MAOB (0.42) | ALDH1A1USP2HPGDHSD17B10 | |
| SCHEMBL7908621 | 0.72 | DDB1 (0.43) | HTR2CDDB1CRBNTAAR1HTR2A | |
| SCHEMBL29698141 | 0.72 | HTR2C (0.47) | HTR2CPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973546-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007081570-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |