Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CTSC | P53634 | 2/20 | 0.33 |
| ▸ | CTSF | Q9UBX1 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306942 | 0.89 | HTR2C (0.45) | HTR2CHTR2AHTR2BPKMPBRM1 | |
| SCHEMBL5129808 | 0.89 | HTR2C (0.45) | HTR2CHTR2AHTR2BPKMPBRM1 | |
| SCHEMBL4310679 | 0.76 | HTR2C (0.49) | HTR2CHTR2AHTR2BPKMHTR6 | |
| SCHEMBL5125493 | 0.76 | HTR2C (0.49) | HTR2CHTR2AHTR2BPKMHTR6 | |
| SCHEMBL28957041 | 0.74 | HTR2C (0.47) | HTR2CPBRM1 | |
| SCHEMBL29698141 | 0.74 | HTR2C (0.47) | HTR2CPBRM1 | |
| SCHEMBL28957039 | 0.74 | HTR2C (0.47) | HTR2CPBRM1 | |
| SCHEMBL13394483 | 0.72 | PKM (0.50) | HTR2CPKMPBRM1DDB1CRBN | |
| SCHEMBL14521456 | 0.71 | MAOB (0.42) | — | |
| SCHEMBL1705219 | 0.71 | MAOB (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973546-B1 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |